@article{Imade2026b,

title = {HPLC analysis and subacute effect of Senna alata (L.) root and Xylopia aethiopica (Dunal) A. Rich seed on steroidal hormones associated with fibroid},

author = {Rose Osarieme Imade and Toluwalase Adu-Fatoba},

url = {https://journal.seoda.org/wp-content/uploads/2026/03/ARTICLE-2-1.pdf},

year  = {2026},

date = {2026-02-15},

urldate = {2026-02-15},

journal = {SEODA Journal of Aromatic and Medicinal Plants },

volume = {1},

abstract = {Uterine fibroids, influenced by estrogen and progesterone, are common benign tumors in women of reproductive age. This work researched the action of Senna alata root and Xylopia aethiopica seed on progesterone and estradiol levels in female Wistar rats. Animal studies were conducted by administering 100 and 200 mg/kg doses of each extract to test animals daily for 28 consecutive days, after which blood samples were collected. Serum was analyzed for estradiol and progesterone levels using standard biochemical assays. High-Performance Liquid Chromatography (HPLC) was employed to identify the phytoconstituents in the ethanol extracts of the plants. S. alata significantly reduced progesterone levels (p\<0.001) at both concentrations, while X. aethiopica showed marked activity only at 200 mg/kg (p\<0.01). Estradiol levels remained unchanged with both extracts. HPLC identified bioactive compounds like kaempferol, trans-resveratrol and adenine in S. alata roots, and beta-phellandrene, kaempferol and umbelliferone in X. aethiopica seeds. These findings suggest hormone regulatory effects of these plants, warranting further research into their efficacy and mechanisms for fibroid management.},

keywords = {Estradiol, Fibroid, HPLC, Progesterone, Senna alata, Xylopia aethiopica},

pubstate = {published},

tppubtype = {article}

}