@article{Imade2026,

title = {Subacute effect of Momordica charantia plant, Tetrapleura tetraptera fruit and Allium cepa bulb on steroidal hormones},

author = {Rose Osarieme Imade and Temitope Jemimah Alakija},

url = {https://journal.seoda.org/wp-content/uploads/2026/03/ARTICLE-1-1.pdf},

year  = {2026},

date = {2026-02-15},

urldate = {2026-02-15},

journal = {SEODA Journal of Aromatic and Medicinal Plants },

volume = {1},

abstract = {Fibroids are hormone-dependent tumors influenced by elevated levels of estradiol and progesterone. The search for natural alternatives to conventional treatments has led to the investigation of plant-based therapies. This study evaluates the phytochemical composition and effect of Momordica charantia L. (Cucurbitaceae) plant, Tetrapleura tetraptera (Schum. \& Thonn.) Taub. (Mimosaceae) fruit and Allium cepa L. (Amaryllidaceae) bulb on serum cholesterol, estradiol, and progesterone implicated in fibroid growth. Animal studies were conducted by administering 100 and 200 mg/kg doses of each plant extract to Wistar rats over 28 days, after which blood samples were collected. Serum was analyzed for changes in cholesterol, estradiol, and progesterone levels using standard biochemical assays. High-Performance Liquid Chromatography was employed to identify the phytoconstituents in the ethanol extracts of the plants. The results showed that A. cepa significantly lowered serum cholesterol levels (p \< 0.05), while M. charantia and T. tetraptera did not produce statistically significant reductions. None of the plant extracts caused a significant decrease in estradiol levels, however, A. cepa and T. tetraptera significantly reduced serum progesterone levels, suggesting potential anti-fibroid activity. Phytochemical analysis confirmed the presence of bioactive compounds that may contribute to these effects. These findings suggest that the tested plant extracts, particularly A. cepa and T. tetraptera, may have potential in managing fibroid growth through hor},

keywords = {Allium cepa, Fibroid, HPLC, Momordica charantia, Steroidal hormones, Tetrapleura tetraptera},

pubstate = {published},

tppubtype = {article}

}